Pyrene Fire
Pyrene Fire
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 Antique Brass Fire Extinguisher For Sale Circa 1930s Pyrene Manf Company NJ  US $95.00
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 VINTAGE BRASS PYRENE FIRE EXTINGUISHER 14 Long US $99.99
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 pyrene fire extinguisher rare vintage chome brass mint pristine condition US $99.99
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 1912 St Louis Missouri Fire Department photo Pyrene extinguisher print ad US $9.99
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 Vintage Antique Essanay Copper Brass Fire Extinguisher LAMP w 3 way touch US $350.00
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 Vintage Pyrene Brass 1 Qt Hand Fire Extinguisher w Mounting Bracket US $82.99
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 Antique Pyrene Brass Copper With Wood Handle Pump Fire Extinguisher OLD Heavy US $170.95
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 Vintage Pyrene Automobile Type Fire Extinguisher with Original Mounting Bracket US $79.95
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 Vintage Antique Old Pyrene Copper Fire Extinguisher US $127.50
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 VINTAGE pyrene 1 1 2 heavy vehicle type fire EXTINGUISHER FIREFIGHTER US $37.00
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 Pyrene Fire Extinguisher Copyright 1917 patent 1907 US $75.00
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 1919 Pyrene Fire Extinguisher Car Fire Color Ad US $6.00
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 Vintage Pyrene Pump Type Fire Extinguisher Heavy Vehicle Type Brass ca 1920s US $59.97
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 CLOSED CAR ON FIRE IN 1923 PYRENE FIRE EXTINGUISHERS AD US $12.98
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 HOME GUARD STATUE IN 1915 PYRENE FIRE EXTIGUISHERS AD US $11.03
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 AUTO CRASH FIRE IN 1924 PYRENE FIRE EXTINGUISHERS AD US $11.03
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 2 VINTAGE BRASS FIRE EXTINGUISHERS PYRENE FRY FYTER US $179.00
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 VINTAGE PYRENE 2 1 2 GAL WATER FIRE EXTINGUISHER US $34.99
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 Two Brass Fire Extinguishers Bracket Pyrene General Quick Aid Empty US $60.00
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 EMPTY Vintage Pyrene Brass Fire Extinguisher 1917 US $60.00
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 Really Cool Vintage EMPTY Brass Pyrene Water Anti Freeze Fire Extinguisher US $75.00
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 Polished Pyrene Brass Pump refillable Fire Extinguisher Rat Rod Kustom Kulture US $38.88
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 VINTAGE BRASS PYRENE FIRE EXTINGUISHER Heavy Vehicle Type Hand Pump w Handle US $40.00
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 PYRENE VINATGE BRASSE HEAVY VEHICLE TYPE FIRE EXTINGUISHER WITH BRACKET US $59.99
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 ANTIQUE BRASS FIRE EXTINGUISHER Pyrene Heavy Vehicle Type EMPTY US $59.99
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 ANTIQUE VINTAGE PYRENE BRASS COPPER 2 1 2 GALLON FIRE EXTINGUISHER US $44.99
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 Vintage pre 1947 Pyrene Push Button Fire Extuinghsher with bracket US $200.00
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 Vintage Pyrene Fire Extinguisher US $120.00
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 Vintage FIRE EXTIGUISHER Dated 3 1968 Stainless Steel 2 1 2 Gal Works US $74.95
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 VINTAGE 5 Gallon Pyrene Pump Water Extinguisher GREAT CONDITION Works US $174.95
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 Pyrene Brass fire extinguisher Dated 1912 176371 US $69.95
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 BRASS FIRE EXTINGISHER PYRENE MFG CO US $29.95
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 Vintage Antique PYRENE Copper Fire Extinguisher 5 Gallon US $199.99
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 Antique Brass Pyrene Fire Extinguisher US $19.99
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 VINTAGE HAND PUMP PYRENE FIRE EXTINGUISHER US $24.99
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 Vintage Pyrene Copper Brass Fire Extinguisher US $150.00
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 PYRENE 2 QUART BRASS EXTINGUISHER PRESSURIZED TYPE CRASH TRUCK US $75.00
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 Vintage The New Super Fyr Fyter Brass fire extinguisher 1 qt Empty pyrene type US $19.99
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 Vintage BrassNickel PYRENE Soda Acid Fire ExtinguisherEmptyHose AttachedNICE US $9.99
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 Antique vintage Pyrene fire extinguisher Empty US $48.00
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 VINTAGE PYRENE SODA ACID FIRE EXTINGUISHER SILVER COLOR RARE GREAT CONDITION US $24.99
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 Old Vintage Pyrene Hand Fire Extinguisher from Canada Limited Brass 78496 US $15.00
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 PYRENE FIRE EXTINGUISHER Empty US $55.00
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 Vintage Antique PYRENE Brass quart fire extinguisher 1 qt w wall mount EMPTY US $26.99
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 Vintage Pyrene Fire Extinguisher with Bracket brass copper with part of tag US $149.00
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 Antique Vintage Solid Brass PYRENE Fire Extinguisher Heavy Vehicle Type EMPTY US $19.99
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 VERY RARE Historic Antique Essanay Soda Fire Extinguisher Fire Fighting Treasure US $55.00
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 Rare Pyrene Fire extinguisher Ashtray rare Ash tray US $13.00
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 Vintage Pyrene Fire Extinguisher Brass Auto w Mounting Bracket Quart Size US $19.99
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 Brass Pyrene Fire Extinguisher with bracket US $12.80
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 VINTAGE ESSANAY COPPER BRASSSODA ACIDFIRE EXTINGUISHER2 1 2 GALLON US $39.99
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 VINTAGE PYRENE COPPER BRASSSODA ACIDFIRE EXTINGUISHER2 1 2 GALLON US $39.99
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 Two Empty Antique Brass Fire Extinguishers Pyrene and Buffalo Better Built US $20.95
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 EMPTY 1917 pyrene fire extinguisher US $40.00
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 VINTAGE FIRE EXTINGUISHERS LAFRANCE PYRENE BOTH EMPTY US $15.00
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 Antique 105 Pyrene Fire Extinguisher With Wall Mount US $9.99
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 buffalo Copper Extinquisher US $60.00
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 Antique Pyrene Fire Extinguisher empty US $34.99
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 PYRENE FIRE EXTINGUISHER US $39.99
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 Antique Essanay Soda Acid Fire Extinguisher US $9.95
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 ELKHART 2 1 2 Gallon Antique Collectable Fire Extinguisher Empty US $245.00
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Inflammatory Disorders and the Increased Occurrence of Mesothelioma
A better understanding of asbestos related diseases is necessary if we are ever to find a cure to Mesothelioma. One interesting study is called, "Immunohistochemical localization of transforming growth factor beta isoforms in asbestos-related diseases." By J Jagirdar, T C Lee, J Reibman, L I Gold, C Aston, R Bégin, and W N Rom - Environ Health Perspect. 1997 September; 105(Suppl 5): 1197–1203. Here is an excerpt: "Abstract - Transforming growth factor beta (TGF-beta), a multifunctional cytokine and growth factor, plays a key role in scarring and fibrotic processes because of its ability to induce extracellular matrix proteins and modulate the growth and immune function of many cell types. These effects are important in inflammatory disorders with fibrosis and cancer. The asbestos-related diseases are characterized by fibrosis in the lower respiratory tract and pleura and increased occurrence of lung cancer and mesothelioma. We performed immunohistochemistry with isoform-specific antibodies to the three TGF-beta isoforms on 16 autopsy lungs from Quebec, Canada, asbestos miners and millers. There was increased immunolocalization of all three TGF-beta isoforms in the fibrotic lesions of asbestosis and pleural fibrosis. The hyperplastic type II pneumocytes contained all three isoforms. By contrast, there was differential spatial immunostaining for the TGF-beta isoforms in malignant mesothelioma, with TGF-beta 1 in the stroma but TGF-beta 2 in the tumor cells. These data are consistent with an important role for TGF-beta in accumulation of extracellular matrix and cell proliferation in asbestos-related diseases."
A second study is called, "Asbestos and Benzo(a)pyrene Synergism in the Transformation of Syrian Hamster Embryo Cells" by Joseph A. DiPaolo, Anthony J. DeMarinis, Jay Doniger - Pharmacology 1983;27:65-73. Here is an excerpt: "Abstract - Four varieties of asbestos fibers, crocidolite, anthophyllite, amosite, and chrysotile, induced a low rate of morphologic transformation in Syrian hamster cells. Of the four tested, chrysotile was the most lethal as reflected by colony survival. When cells were exposed to 1 μg of benzo(a)pyrene (BP)&slash;l ml medium or 3 J/m2 ultraviolet irradiation and to different concentrations of the asbestos fibers, an enhancement of transformation occurred only with BP. The enhancement was dose responsive with all fiber species except for amosite which was dose independent. The synergistic activity of BP and asbestos suggests that asbestos facilitates the transport of BP to the cell site(s) critical for transformation. These results provide a basis for investigating the carcinogenic and cocarcinogenic potential of asbestos fibers in mammalian cells."
Another interesting study is called, "Interaction of asbestos with alveolar cells" by Yasunosuke Suzuki - Environ Health Perspect. 1974 December; 9: 241–252. Here is an excerpt: "Abstract - A number of electron microphotographs are presented showing the various aspects of phagocytosis of fibers in lung tissue. The fibers were rapidly phagocytosed by alveolar macrophages, by polymorphonuclear leucocytes, and less frequently by alveolar epithelial cells. They were also found in the cytoplasm of the alveolar stromal macrophages. In the late stage of the disease, macrophages containing the minerals were recognized in the fibrous submesothelial connective tissues. In this stage, a cell intermediate in structure between the epithelial cell and the macrophage was observed in the alveolar lining. This cell showed strong phagocytic activity against the fibers.The process of phagocytosis of the fibers was quite similar to that of other microparticles such as Thorotrast and India ink. It had been suggested that phagosomes containing the fibers became transformed into secondary lysosomes.The fate of the phagocytosed fibers varied. Some were partly dissolved or digested with marked reduction in the thickness of the wall of the chrysotile fibril. Many became coated by hemosiderin which accumulated in the cytoplasm of the phagocytic cells. This coating transformed the fibers into asbestos bodies. Finally many fibers were released because of the death of the host cell. Uncoated fibers as well as various stages of phagocytosis were observed in all animals, including those 1 to 2 years after the instillation of asbestos. This strongly suggests that fibers may be repeatedly phagocytosed, released and ephagocytosed, inducing a continuous response of the alveolar cells and maintaining the disease."
We all owe a debt of gratitude to these fine researchers for their hard work and dedication. If you found any of these excerpts interesting, please read the studies in their entirety.
About the Author
Monty Wrobleski is the author of this article, for more information please visit the following links